Download e-book for iPad: Advances in Peptic Ulcer Pathogenesis by W.D. Rees

By W.D. Rees

ISBN-10: 0746200625

ISBN-13: 9780746200629

ISBN-10: 9401070520

ISBN-13: 9789401070522

over the last decade loads of study task has happened on each side of the gastroduodenal epithelial interface, with the typical target of elucidating the mechanisms of mucosal security and the way those might be compromised in peptic ulcer ailment. a primary stimulus to such examine has been the conclusion that irregular acid secretion or its supply into the duodenum in over the top volume can't absolutely clarify ulcer pathogenesis within the majority of sufferers. One may well envisage the tummy and proximal duodenum as being in a dynamic equilibrium, with competitive luminal components, equivalent to acid and pepsin, being counteracted by means of protecting mucosal mechanisms. till lately, the mechanisms keen on mucosal safeguard were poorly outlined whereas the body structure and pathophysiology of acid and pepsin secretion have been elucidated. The impact that gastroduodenal mucosa used to be secure through a unmarried mechanism has eventually been changed through a extra reasonable view, suggesting a few protecting zones performing in sequence. a few of these zones might act as first or moment line defences opposed to competitive elements whereas definite zones may well in particular safeguard opposed to yes aggressors.

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Advances in Peptic Ulcer Pathogenesis by W.D. Rees

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